Plot
Scooby-Doo and the Mystery Inc. gang solve more mysteries together, each time with a different living, late or fictional celebrity guest.
Cast
| Name | Role |
|---|---|
| Frank Welker | Fred Jones |
| Grey Griffin | Daphne Blake |
| Matthew Lillard | Shaggy Rogers |
| Kate Micucci | Velma Dinkley |
| Kevin Michael Richardson | Big Bob |
| Dee Bradley Baker | Monster |
| Phil LaMarr | Caddy |
| Stephen Stanton | Big Eddy |
| Kari Wahlgren | Anchorwoman |
| Mark Hamill | Joker |
| Keith Ferguson | Announcer |
| Robbie Daymond | Cache Blanc |
| Kimberly Brooks | Dance Teacher |
| John DiMaggio | Abe Lincoln |
| Rachel Kimsey | Marla |
| Charlie Schlatter | Announcer |
| Tom Kenny | Augie Anderson |
| Fred Tatasciore | Actor |
| Billy West | Arnie |
| Jess Harnell | Ghost Knight |
| Jeff Bennett | Beefeater Guard |
| JB Blanc | Antiques Dealer |
| Kevin Conroy | Batman |
| Jim Gaffigan | Jim Gaffigan |
| Whoopi Goldberg | Whoopi Goldberg |
| Penn Jillette | Penn Jillette |
| Chris Paul | Chris Paul |
| Sia | Sia |
| Wanda Sykes | Wanda Sykes |
| Kenan Thompson | Kenan Thompson |
| 'Weird Al' Yankovic | 'Weird Al' Yankovic |
| Laila Ali | Laila Ali |
| Sean Astin | Delivery Man |
| Steve Buscemi | Paolo |
| Joey Chestnut | Joey Chestnut |
| Trevor Devall | Cameraman |
| Robin Atkin Downes | Elevator Operator |
| Sandy Duncan | Sandy Duncan |
| Jeff Dunham | Jeff Dunham |
| Kevin Durand | Caretaker |
| Jeff Foxworthy | Jeff Foxworthy |
| Halsey | Halsey |
| Liza Koshy | Liza Koshy |
| Tara Lipinski | Tara Lipinski |
| Macklemore | Macklemore |
| Malcolm McDowell | Malcolm McDowell |
| Dave B. Mitchell | Perry John Lupointe |
| George Takei | George Takei |
| Ian James Corlett | Sherlock Holmes |
| Ricky Gervais | Ricky Gervais |
| Teller | Teller |
| Jaleel White | Steve Urkel |
| Alton Brown | Alton Brown |
| Darci Lynne Farmer | Darci Lynne Farmer |
| Morgan Freeman | Morgan Freeman |
| Johnny Gilbert | Johnny Gilbert |
| Tim Gunn | Tim Gunn |
| Gigi Hadid | Gigi Hadid |
| David Kaye | Angry Chef |
| Chloe Kim | Chloe Kim |
| Andrew Kishino | Caterer |
| Maurice LaMarche | Caretaker |
| John Mariano | Angry Italian Man |
| Kacey Musgraves | Kacey Musgraves |
| Bill Nye | Bill Nye |
| Kristen Schaal | Kristen Schaal |
| Jill Talley | Construction Foreperson |
| Maddie Ziegler | Maddie Ziegler |
| Steven Weber | Alfred Pennyworth |
| Jennifer Hale | Thorn |
| Christian Slater | Christian Slater |
| Alex Trebek | Alex Trebek |
| Neil deGrasse Tyson | Neil deGrasse Tyson |
| Jane Wiedlin | Dusk |
| Jason Sudeikis | Jason Sudekeis |